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来自沃勒姆研究所（OHSU）桑德斯实验室，一个构建组合DNA条码库的框架，使得基于探针的基因组学平台能够大规模跟踪和解码实验操作。
实验室描述了一种组合条码架构，使得使用768个探针解码约1680万个独特的RNA条码。团队与科学家合作，使用六个已知示例条码与狂犬病毒载体导入小鼠大脑，验证了体内解码。由于返回的是真实的x、y、z解码坐标而非二维投影，团队能够对条码特定解码事件进行评分，并利用三维空间聚类将这些点分割为单一视场内的264个独立神经元，恢复条码身份，并区分单次和多次感染事件。
条码可以轻松地用于单细胞分辨率的多种高度复用实验操作追踪，包括基因组级CRISPR筛查、谱系追踪和直接在完整厚组织中读取的突触网络重建。桑德斯实验室开发的组合条码设计与组装框架非常适合设计新型条码方案，以满足现有及未来基于探针的基因组学技术的需求。
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When #AI advice takes a wrong turn! #InnovativeTsinghua team, led by Prof. Huang Minlie from the 清华大学计算机系 Tsinghua University Department of Computer Science and Technology, revealed that covertly misaligned AI advice can shift choices away from #optimal options across both financial and emotional decisions in PNAS. This finding has implications for the design and #governance of AI-mediated advice.
For more: bit.ly/4heJbPO
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MAHE Nobel Insights 2026: Physiology or Medicine
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Clinical trial shows significant gain in gut diversity alongside improved quality-of-life scores; DynaMAP validated against sequencing for microbiome read-outs.
What mattered just as much was speed. DynaMAP gave us results with a turnaround time fast enough that we weren’t waiting weeks to know if the formulation was doing what we designed it to do.”— Didier PerezPALM SPRINGS, CA, UNITED STATES, September 29, 2026 /EINPresswire.com/ -- PhenoBiome today reported results from its MAPLE clinical trial, an eight-week study of a personalized nutritional (prebiotic) supplement in adults, run in collaboration with Perseus Biomics using the DynaMAP microbiome-profiling platform. The trial met its primary microbiome endpoint: species-level Shannon diversity rose by 0.55 points (from 4.91 to 5.46; p = 0.010) across the twelve completers, with eight of twelve gaining diversity against their own baseline.
The gain came from sub-dominant species rather than a reshuffling of the community’
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肠道健康，身体才健康——这个道理我们都听过。可为什么吃着差不多的家常菜，有的人肠胃舒服、远离大病，有的人却早早被肠癌、顽固的肠炎、糖尿病找上门？过去，我们习惯把问题归咎于“益生菌不够”或“坏菌太多”。而2026年5月国际顶刊《Nature》上的一篇研究刷新了我们的理解：你肠道里的微生物世界，远非简单的正邪对立，而更像一个暗流涌动的“江湖”，其中不同“帮派”的势力消长，才是影响你健康走向的关键。
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Events including running, high jump and free‑fight take place one after another, where robot athletes show their full capabilities. Sports competition meets cutting‑edge technology, creating a collision between traditional arenas and futuristic vibes. Come witness this one‑of‑a‑kind tech gala and enjoy a distinctive event experience.
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Date: Nov 16‑18, 2026
Venue: Halls N1‑N5, E6‑E7, Shanghai New International Expo Center
Exhibition site of analytica China
Exhibition Zone: Life Science Pavilion
Official Website: https://www.analyticachina.com.cn
Cell‑analysis‑related Zone: Hall N3/N4/N5, Life Science, Biotechnology & Diagnostics Pavilion
Displayed Instruments: Live‑cell imaging systems, flow cytometers, single‑cell sequencing platforms, cell metabolism analyzers, high‑throughput cell screening systems, microfluidic cell‑analysis devices, cell‑culture monitoring instruments.
Highlights: World‑leading cell‑instrument manufacturers showcase new products; themed forums on cell analysis and synthetic biology will be held concurrently.
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Teams led by Qiao Yan and Wang Shu from the Chinese Academy of Sciences constructed an artificial‑cell model to simulate the asymmetric division of natural cells: one mother cell divides into two daughter artificial cells with completely distinct morphologies and functions. This achievement helps elucidate the origin of cell differentiation in primitive life and advances the development of synthetic cells and biomanufacturing.
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