Cyto-Mine: Accelerating Antibody Discovery and Cell Line Development

Cyto-Mine® is a state-of-the-art, automated platform designed to revolutionize biopharmaceutical discovery and cell line development. By integrating advanced technologies, Cyto-Mine® simplifies and accelerates the entire cell line development process, from cell encapsulation and assay integration to monoclonality assurance and high-throughput screening.

A unique and gentle workflow to find those rare gems

Cyto-Mine® is our high-throughput platform using picodroplet technology and microfluidics to process up to 40 million heterogeneous mammalian cells (in pools) in less than a day! While principally designed for antibody discovery and cell line development, Cyto-Mine® is an extremely flexible platform, making it ideal for a wide variety of application areas.

Next Generation Technology

Current processes for finding novel antibody targets or developing stable cell lines are time-consuming, often inefficient, and difficult to scale. Cyto-Mine® breaks down the barriers that current processes can bring, such as low throughput, or imposing harsh conditions on cells impacting viability and outgrowth, or not allowing direct measurement of cell secretion. Our platform provides the next generation of technology to provide automated, accurate, cost-effective high-throughput screening with gentle processing and reduced contamination.

Discover our Cyto-Cellect®PLUS FRET assay application note

Cyto-Cellect®PLUS detects the presence of human IgG kappa and lambda light chains, compatible ith the Cyto-Mine®.

With Cyto-Mine® you can achieve:

l  Targeted Discovery: Rapidly identify and isolate your rare cells of interest.

l  Monoclonality Assurance: Extensive proof of monoclonality is critical for cell line development.

l  Save Time and Costs: Tens of millions of cells in pools or hundreds of thousands individually can be screened in a single day.

l  Flexibility: Flexible assay designs allow quantitative measurement of antibody secretion and other detection methodologies.

l  GLP Compliance: The entire process is automated utilizing Animal Origin Free reagents. The Benchtop system is compatible for use in Class II biosafety cabinets.

l  Regulatory Compatibility:Cyto-Mine® is 21 CFR Part 11-compliant.

Built on picodroplet technology

At the heart of our platforms are picodroplets. These are tiny droplets of aqueous fluid in an oil carrier fluid (‘single aqueous’), or an aqueous core surrounded by an oil shell in an aqueous carrier fluid ( ‘double aqueous’).

Each picodroplet is used to encapsulate a cell. This provides an ultra-miniaturized test tube, containing media, reagents and cells, that allows large-scale experiments at the single cell level.

These droplets can then be processed to build complex workflows to find the cells you care about.

Applications: